Vascular-targeted photodynamic therapy (V-PDT) is an effective treatment for port wine stains (PWS). However, repeated treatment is usually needed to achieve optimal treatment outcomes, possibly due to the limited treatment light penetration depth in the PWS lesion. The optical clearing technique can increase light penetration in depth by reducing light scattering. This study aimed to investigate the V-PDT in combination with an optical clearing agent (OCA) for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber model. Vascular responses were closely monitored with laser speckle contrast imaging (LSCI), optical coherence tomography angiography, and stereo microscope before, during, and after the treatment. We further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin microvasculature. The combination of OCA and V-PDT resulted in significant vascular damage, including vasoconstriction and the reduction of blood flow. Our results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases, including PWS.

利用IRTracer-100傅里叶变换红外光谱仪测量了柴油介质的光谱数据，根据光谱数据反演柴油介质的光学常数，分析不同温度对柴油透射光谱及光学常数的影响。研究结果表明: 在波段400~2000cm-1范围内存在470cm-1、1377cm-1、1454cm-13个吸收区域; 柴油的折射率对光谱的选择性很强，吸收指数呈现波动性变化; 在波段905~1200cm-1范围内，柴油的折射率随波长增加波动性较大，吸收指数随温度升高而明显下降，25℃波数为939cm-1时吸收指数存在最大值0.01523; 在波段1800~2100cm-1范围内，柴油的折射率随温度升高而增大，吸收指数在2085cm-1存在最大值0.00738。

探索了长短脉冲复合激光在铝材损伤方面的应用。基于激光与材料相互作用的热效应原理, 讨论了材料表面反射率、激光与材料耦合系数等对损伤机制的影响, 数值计算了长脉冲激光辐照对2A12铝材的热效应、短脉冲激光对铝材的冲击压强及损伤时间。设计了长短脉冲复合激光辐照实验系统。结果表明, 设计的长短脉冲复合激光器能够实现对2A12铝材的有效快速损伤, 损伤效果好于单独的长脉冲或短脉冲作用, 有效降低了损伤时间。

通过使用多目标遗传算法对回旋行波放大器加载分布式损耗的电阻率和厚度参数进行优化，得出了两个参数的最佳组合值：损耗层厚度0.116 mm，电阻率为铜的77 882倍，此时放大器达到最大增益15.9 dB。并且通过单目标遗传算法对该值的准确性进行了验证，使得放大器在有效抑制回旋返波振荡的同时实现了增益的最大化。

载玻片在液体光学测量、微生物学和基因学等领域实验中应用广泛, 其光学性能直接影响实验结果。提出了透射法测量载玻片光学常数的方法, 建立了载玻片透射比计算模型及其光学常数反演模型。通过TU-19双光束可见光分光光度计测量1.5mm和2.0mm厚度载玻片样品在310~600nm波长范围的透射光谱, 结合透射光谱利用光学常数反演模型, 得到了载玻片的光学常数。结果表明, 载玻片的衰减系数在10-6~10-8之间, 折射率在1.5~3.3之间。

Path protections have become increasingly important for current mesh optical networks because fast restorations in generalized multiprotocol label switching (GMPLS) networks are uncertain. However, setting up additional disjoint paths to protect connections leads to more path setup blocking and signaling collisions. We analyze signaling collisions, path blocking and blocking probability, as well as calculate node-to-node blocking probabilities. A signaling-based path-segment protection (PSP) is proposed, which integrates segment protections and path protections as well as enhances the performance of path protections and ring protections. The setup of PSP connections causes less blocking probability than the setup of path protection connections in the simulations.